🧬 基因注释：U2AF1
📝 官方信息
官方名称：U2 small nuclear RNA auxiliary factor 1
功能摘要：This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
🎯 作为靶基因的剪接因子
- Tardbp 综合评分: 0.418 · 证据 1 条
- Srsf3 综合评分: 0.398 · 证据 1 条
- FUS 综合评分: 0.362 · 证据 1 条
- HNRNPK 综合评分: 0.362 · 证据 2 条
- HNRNPL 综合评分: 0.362 · 证据 2 条
- KHSRP 综合评分: 0.362 · 证据 2 条
- RBFOX2 综合评分: 0.362 · 证据 2 条
- SRSF2 综合评分: 0.362 · 证据 1 条
- fus 综合评分: 0.362 · 证据 1 条
- HNRNPA2B1 综合评分: 0.350 · 证据 2 条
- HNRNPC 综合评分: 0.350 · 证据 2 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- U2af1 综合评分: 0.346 · 证据 1 条
- EWSR1 综合评分: 0.312 · 证据 2 条
- RBM10 综合评分: 0.312 · 证据 2 条
- RBM22 综合评分: 0.312 · 证据 2 条
- TIA1 综合评分: 0.312 · 证据 1 条
- HNRNPU 综合评分: 0.300 · 证据 2 条
- PTBP1 综合评分: 0.300 · 证据 2 条
🏥 关联疾病
acute myeloid leukemia
中关联 (0.565)
lung adenocarcinoma
中关联 (0.513)
neurodegenerative disease
中关联 (0.501)
myelodysplastic syndrome
中关联 (0.457)
non-small cell lung carcinoma
中关联 (0.439)
chronic myelomonocytic leukemia
低关联 (0.373)
myelofibrosis
低关联 (0.372)
chronic myelogenous leukemia
低关联 (0.372)
lung carcinoma
低关联 (0.372)
therapy related acute myeloid leukemia and myelodysplastic syndrome
低关联 (0.370)