🧬 基因注释：U2AF2
📝 官方信息
官方名称：U2 small nuclear RNA auxiliary factor 2
功能摘要：U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008].
🎯 作为靶基因的剪接因子
- HNRNPL 综合评分: 0.424 · 证据 2 条
- PTBP1 综合评分: 0.424 · 证据 2 条
- RBFOX2 综合评分: 0.424 · 证据 2 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- HNRNPM 综合评分: 0.412 · 证据 2 条
- QKI 综合评分: 0.412 · 证据 1 条
- SRSF2 综合评分: 0.362 · 证据 1 条
- SRSF9 综合评分: 0.362 · 证据 1 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- HNRNPC 综合评分: 0.350 · 证据 2 条
- HNRNPF 综合评分: 0.350 · 证据 2 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- PRPF8 综合评分: 0.324 · 证据 1 条
- FUBP1 综合评分: 0.312 · 证据 2 条
- RBM10 综合评分: 0.312 · 证据 2 条
- RBM15 综合评分: 0.312 · 证据 2 条
- RBM39 综合评分: 0.312 · 证据 2 条
- Srsf1 综合评分: 0.310 · 证据 1 条
- U2af1 综合评分: 0.310 · 证据 1 条
🏥 关联疾病
developmental delay, dysmorphic facies, and brain anomalies
中关联 (0.644)
Neurodevelopmental disorder
中关联 (0.585)
genetic disorder
中关联 (0.467)
Intellectual disability
中关联 (0.463)
acute myeloid leukemia
低关联 (0.372)
dengue disease
低关联 (0.370)
neurodegenerative disease
低关联 (0.354)
leukodystrophy
低关联 (0.259)