🧬 基因注释：UBA3

官方名称：ubiquitin like modifier activating enzyme 3

功能摘要：The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

• HNRNPC 综合评分: 0.510 · 证据 2 条
• HNRNPM 综合评分: 0.448 · 证据 2 条
• RBFOX2 综合评分: 0.444 · 证据 2 条
• FUS 综合评分: 0.398 · 证据 1 条
• PTBP1 综合评分: 0.398 · 证据 2 条
• fus 综合评分: 0.398 · 证据 1 条
• HNRNPL 综合评分: 0.362 · 证据 2 条
• HNRNPA2B1 综合评分: 0.350 · 证据 2 条
• MBNL1 综合评分: 0.350 · 证据 2 条
• Tardbp 综合评分: 0.336 · 证据 1 条
• FUBP1 综合评分: 0.312 · 证据 2 条
• RBM15 综合评分: 0.312 · 证据 2 条
• HNRNPU 综合评分: 0.300 · 证据 2 条
• KHSRP 综合评分: 0.300 · 证据 2 条
• PRPF8 综合评分: 0.262 · 证据 1 条
• U2af2 综合评分: 0.260 · 证据 1 条
• EWSR1 综合评分: 0.250 · 证据 2 条
• RBM10 综合评分: 0.250 · 证据 2 条
• TIA1 综合评分: 0.250 · 证据 1 条
• Rnps1 综合评分: 0.224 · 证据 1 条

该基因暂无关联疾病记录