🧬 基因注释：UBE2K
📝 官方信息
官方名称：ubiquitin conjugating enzyme E2 K
功能摘要：The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
🎯 作为靶基因的剪接因子
- HNRNPC 综合评分: 0.536 · 证据 2 条
- RBFOX2 综合评分: 0.444 · 证据 2 条
- MBNL2 综合评分: 0.442 · 证据 1 条
- HNRNPK 综合评分: 0.424 · 证据 2 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- HNRNPH1 综合评分: 0.412 · 证据 2 条
- FUS 综合评分: 0.398 · 证据 1 条
- Srsf2 综合评分: 0.398 · 证据 1 条
- fus 综合评分: 0.398 · 证据 1 条
- KHSRP 综合评分: 0.362 · 证据 2 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- QKI 综合评分: 0.350 · 证据 1 条
- Tardbp 综合评分: 0.336 · 证据 1 条
- PRPF8 综合评分: 0.324 · 证据 1 条
- RBM10 综合评分: 0.312 · 证据 2 条
- RBM22 综合评分: 0.312 · 证据 2 条
- TIA1 综合评分: 0.312 · 证据 1 条
- Srsf1 综合评分: 0.310 · 证据 1 条
🏥 关联疾病
该基因暂无关联疾病记录