🧬 基因注释：UBQLN1

官方名称：ubiquilin 1

功能摘要：This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

• HNRNPC 综合评分: 0.494 · 证据 2 条
• FUS 综合评分: 0.486 · 证据 1 条
• fus 综合评分: 0.486 · 证据 1 条
• HNRNPM 综合评分: 0.448 · 证据 2 条
• HNRNPL 综合评分: 0.362 · 证据 2 条
• HNRNPU 综合评分: 0.362 · 证据 2 条
• PTBP1 综合评分: 0.362 · 证据 2 条
• HNRNPA1 综合评分: 0.350 · 证据 2 条
• HNRNPA2B1 综合评分: 0.350 · 证据 2 条
• HNRNPH1 综合评分: 0.350 · 证据 2 条
• MBNL1 综合评分: 0.350 · 证据 2 条
• Tardbp 综合评分: 0.336 · 证据 1 条
• CELF2 综合评分: 0.324 · 证据 2 条
• EWSR1 综合评分: 0.312 · 证据 2 条
• ELAVL3 综合评分: 0.306 · 证据 1 条
• HNRNPD 综合评分: 0.300 · 证据 2 条
• HNRNPK 综合评分: 0.300 · 证据 2 条
• KHSRP 综合评分: 0.300 · 证据 2 条
• RBFOX2 综合评分: 0.300 · 证据 2 条
• SRSF2 综合评分: 0.300 · 证据 1 条

该基因暂无关联疾病记录