🧬 基因注释：UNC45B
📝 官方信息
官方名称：unc-45 myosin chaperone B
功能摘要：This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
🎯 作为靶基因的剪接因子
- HNRNPC 综合评分: 0.510 · 证据 2 条
- HNRNPA1 综合评分: 0.448 · 证据 2 条
- HNRNPM 综合评分: 0.448 · 证据 2 条
- HNRNPK 综合评分: 0.424 · 证据 2 条
- PTBP1 综合评分: 0.398 · 证据 2 条
- RBFOX2 综合评分: 0.362 · 证据 2 条
- SRSF9 综合评分: 0.362 · 证据 1 条
- PRPF8 综合评分: 0.324 · 证据 1 条
- RBM22 综合评分: 0.312 · 证据 2 条
- HNRNPU 综合评分: 0.300 · 证据 2 条
- Srsf1 综合评分: 0.274 · 证据 1 条
- U2af1 综合评分: 0.274 · 证据 1 条
- SF3A3 综合评分: 0.262 · 证据 1 条
- Tra2a 综合评分: 0.224 · 证据 1 条
- CPSF6 综合评分: 0.212 · 证据 2 条
- Tardbp 综合评分: 0.212 · 证据 1 条
- HNRNPUL1 综合评分: 0.198 · 证据 1 条
- Rbmx 综合评分: 0.198 · 证据 1 条
- U2af2 综合评分: 0.198 · 证据 1 条
- SAFB2 综合评分: 0.162 · 证据 1 条
🏥 关联疾病
该基因暂无关联疾病记录