🧬 基因注释：UPF3A

官方名称：UPF3A regulator of nonsense mediated mRNA decay

功能摘要：This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017].

• PTBP1 综合评分: 0.506 · 证据 2 条
• HNRNPC 综合评分: 0.494 · 证据 2 条
• HNRNPH1 综合评分: 0.448 · 证据 2 条
• HNRNPA2B1 综合评分: 0.412 · 证据 2 条
• HNRNPK 综合评分: 0.398 · 证据 2 条
• KHSRP 综合评分: 0.398 · 证据 2 条
• HNRNPM 综合评分: 0.350 · 证据 2 条
• CELF2 综合评分: 0.346 · 证据 2 条
• PRPF8 综合评分: 0.324 · 证据 1 条
• RBM39 综合评分: 0.312 · 证据 2 条
• FUS 综合评分: 0.300 · 证据 1 条
• HNRNPU 综合评分: 0.300 · 证据 2 条
• RBFOX2 综合评分: 0.300 · 证据 2 条
• SRSF2 综合评分: 0.300 · 证据 1 条
• fus 综合评分: 0.300 · 证据 1 条
• CSTF2 综合评分: 0.274 · 证据 2 条
• PCBP2 综合评分: 0.262 · 证据 1 条
• CSTF2T 综合评分: 0.260 · 证据 2 条
• EWSR1 综合评分: 0.250 · 证据 2 条
• RBM10 综合评分: 0.250 · 证据 2 条

该基因暂无关联疾病记录