🧬 基因注释：VKORC1

官方名称：vitamin K epoxide reductase complex subunit 1

功能摘要：This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].

• RBFOX2 综合评分: 0.474 · 证据 2 条
• HNRNPC 综合评分: 0.412 · 证据 2 条
• FUS 综合评分: 0.398 · 证据 1 条
• fus 综合评分: 0.398 · 证据 1 条
• PTBP1 综合评分: 0.362 · 证据 2 条
• MBNL1 综合评分: 0.350 · 证据 2 条
• PCBP2 综合评分: 0.344 · 证据 1 条
• RBM15 综合评分: 0.312 · 证据 2 条
• TIA1 综合评分: 0.312 · 证据 1 条
• HNRNPK 综合评分: 0.300 · 证据 2 条
• SRSF3 综合评分: 0.300 · 证据 1 条
• SRSF9 综合评分: 0.300 · 证据 1 条
• Tardbp 综合评分: 0.274 · 证据 1 条
• PRPF8 综合评分: 0.262 · 证据 1 条
• Rbmx 综合评分: 0.260 · 证据 1 条
• UPF1 综合评分: 0.260 · 证据 1 条
• EWSR1 综合评分: 0.250 · 证据 2 条
• U2af1 综合评分: 0.248 · 证据 1 条
• U2af2 综合评分: 0.244 · 证据 1 条
• AQR 综合评分: 0.212 · 证据 1 条

该基因暂无关联疾病记录