🧬 基因注释：VPS72

官方名称：vacuolar protein sorting 72 homolog

功能摘要：The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012].

• PTBP1 综合评分: 0.486 · 证据 2 条
• HNRNPC 综合评分: 0.448 · 证据 2 条
• HNRNPA2B1 综合评分: 0.412 · 证据 2 条
• RBFOX2 综合评分: 0.362 · 证据 2 条
• SRSF2 综合评分: 0.362 · 证据 1 条
• Srsf3 综合评分: 0.362 · 证据 1 条
• PCBP2 综合评分: 0.360 · 证据 1 条
• HNRNPH1 综合评分: 0.350 · 证据 2 条
• MBNL1 综合评分: 0.350 · 证据 2 条
• TIA1 综合评分: 0.312 · 证据 1 条
• FUS 综合评分: 0.300 · 证据 1 条
• HNRNPU 综合评分: 0.300 · 证据 2 条
• SRSF3 综合评分: 0.300 · 证据 1 条
• fus 综合评分: 0.300 · 证据 1 条
• Tardbp 综合评分: 0.294 · 证据 1 条
• CSTF2 综合评分: 0.274 · 证据 2 条
• U2af1 综合评分: 0.274 · 证据 1 条
• PRPF8 综合评分: 0.262 · 证据 1 条
• U2af2 综合评分: 0.260 · 证据 1 条
• RBM10 综合评分: 0.250 · 证据 2 条

该基因暂无关联疾病记录