基因注释 - ZCRB1

📝 官方信息

官方名称：zinc finger CCHC-type and RNA binding motif containing 1

功能摘要：Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008].

🎯 作为靶基因的剪接因子

HNRNPA2B1 综合评分: 0.412 · 证据 2 条
FUS 综合评分: 0.398 · 证据 1 条
fus 综合评分: 0.398 · 证据 1 条
RBFOX2 综合评分: 0.362 · 证据 2 条
HNRNPC 综合评分: 0.350 · 证据 2 条
HNRNPF 综合评分: 0.350 · 证据 2 条
RBM10 综合评分: 0.312 · 证据 2 条
KHSRP 综合评分: 0.300 · 证据 2 条
PTBP1 综合评分: 0.300 · 证据 2 条
RBM15 综合评分: 0.250 · 证据 2 条
RBM39 综合评分: 0.250 · 证据 2 条
TIA1 综合评分: 0.250 · 证据 1 条
Srsf1 综合评分: 0.248 · 证据 1 条
Tardbp 综合评分: 0.248 · 证据 1 条
Rnps1 综合评分: 0.224 · 证据 1 条
U2af1 综合评分: 0.212 · 证据 1 条
PCBP2 综合评分: 0.200 · 证据 1 条
PRPF8 综合评分: 0.200 · 证据 1 条
Ptbp2 综合评分: 0.200 · 证据 1 条
CSTF2T 综合评分: 0.162 · 证据 2 条

🏥 关联疾病

neurodegenerative disease

中关联 (0.523)

COVID-19

低关联 (0.370)

acute myeloid leukemia

低关联 (0.370)

severe acute respiratory syndrome

低关联 (0.370)

gout

低关联 (0.266)

Abnormality of the skeletal system

低关联 (0.208)

hypothyroidism

低关联 (0.196)

🔍 查看该基因的所有关联疾病

🔗 外部数据库链接

NCBI Gene GenBank Ensembl GeneCards UniProt

🧬 基因注释：ZCRB1