🧬 基因注释：ZFR
📝 官方信息
官方名称：zinc finger RNA binding protein
功能摘要：This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expression of this gene is regulated through alternative polyadenylation that mediates differential microRNA targeting. Elevated expression of this gene has been observed in human patients with pancreatic cancer and knockdown of this gene may result in reduced viability and invasion of pancreatic cancer cells. [provided by RefSeq, Sep 2016].
🎯 作为靶基因的剪接因子
- HNRNPC 综合评分: 0.494 · 证据 2 条
- RBFOX2 综合评分: 0.474 · 证据 2 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- QKI 综合评分: 0.412 · 证据 1 条
- TIA1 综合评分: 0.410 · 证据 1 条
- EWSR1 综合评分: 0.394 · 证据 2 条
- Tardbp 综合评分: 0.392 · 证据 1 条
- MBNL2 综合评分: 0.374 · 证据 1 条
- ELAVL3 综合评分: 0.363 · 证据 1 条
- Srsf3 综合评分: 0.362 · 证据 1 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- CELF2 综合评分: 0.336 · 证据 2 条
- Mbnl2 综合评分: 0.324 · 证据 1 条
- PCBP2 综合评分: 0.324 · 证据 1 条
- FUBP1 综合评分: 0.312 · 证据 2 条
- FUS 综合评分: 0.300 · 证据 1 条
- HNRNPD 综合评分: 0.300 · 证据 2 条
- HNRNPK 综合评分: 0.300 · 证据 2 条
- HNRNPL 综合评分: 0.300 · 证据 2 条
🏥 关联疾病
neurodegenerative disease
中关联 (0.483)
autosomal recessive spastic paraplegia type 71
低关联 (0.370)
hyperaldosteronism
低关联 (0.331)
Abruptio Placentae
低关联 (0.325)
ovarian dysfunction
低关联 (0.257)
hearing loss
低关联 (0.252)
Sensorineural hearing impairment
低关联 (0.246)
Hypervolemia
低关联 (0.244)
parasitic infection
低关联 (0.220)
pure or complex autosomal recessive spastic paraplegia
低关联 (0.193)